Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes
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چکیده
منابع مشابه
Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint
BACKGROUND Missegregation of chromosomes during meiosis in human females causes aneuploidy, including trisomy 21, and is thought also to be the major cause of age-related infertility. Most errors are thought to occur at the first meiotic division. The high frequency of errors raises questions as to whether the surveillance mechanism known as the spindle assembly checkpoint (SAC) that controls t...
متن کاملSpindle Assembly Checkpoint in oocytes and zygotes and its importance for human aneuploidy
The surveillance mechanism called Spindle Assembly Checkpoint (SAC) monitors the status of the division spindle and prevents anaphase entry in the presence of anomalies that could result in erroneous segregation of the chromosomes. Disturbances in SAC activity during female meiosis promotes formation of aneuploid oocytes and results in associated reproductive disorders like pregnancy loss or bi...
متن کاملMeiotic spindle, spindle checkpoint and embryonic aneuploidy.
In mitosis, a spindle checkpoint plays important roles at the metaphase-anaphase transition to ensure the formation of a bipolar spindle, the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase. Components of the spindle checkpoint were first identified through genetic screens in budding yeast and some ch...
متن کاملRoles of MAPK and Spindle Assembly Checkpoint in Spontaneous Activation and MIII Arrest of Rat Oocytes
Rat oocytes are well known to undergo spontaneous activation (SA) after leaving the oviduct, but the SA is abortive with oocytes being arrested in metaphase III (MIII) instead of forming pronuclei. This study was designed to investigate the mechanism causing SA and MIII arrest. Whereas few oocytes collected from SD rats at 13 h after hCG injection that showed 100% of mitogen-activated protein k...
متن کاملDNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint
Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a pathway involving the spindle assembly checkpoint (SAC) in response to chemically induced double strand breaks, UVB and ionizing radiation. DNA dama...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms4444